Missouri Secondary State Route E is a north-south highway in South-Central Monroe County. It runs from Missouri State Route 107/154, near Florida, to Missouri Secondary State Route D, near Santa Fe. MO Sec St Rt E does not pass through any towns in Monroe County. MO Sec St Rt E is not multi-plexed in Monroe County. MO Sec St Rt E intersects the following highways in Monroe County. Missouri State Route 107, near Florida. Missouri State Route 154, near Florida.