Missouri State Route 22 runs east-west in West-Central Audrain County. It runs from the Audrain/Boone County Line to Mexico. MO St Rt 22 passes through the following towns in Audrain County. Thompson Mexico
MO St Rt 22 intersects the following highways in Audrain County. Missouri Secondary State Route E, near Thompson. Missouri Secondary State Route NN, near Thompson. Missouri State Route 15, at Mexico.
Missouri Secondary State Route FF, at Mexico. BUSN U.S. Rt. 54, at Mexico.