Missouri State Route 6 is an east-west highway across Central Adair County. It runs from the Adair/Knox County Line, near Brashear, to the Adair/Sullivan County Line, near Green Castle. MO St Rt 6 passes through the following towns in Adair County. Brashear
WB MO St Rt 6 at the Adair/Knox County Line. WB MO St Rt 6 near Gibbs. WB MO St Rt 6 east of Kirksville. NB U.S. Rt. 63/MO St Rt 11; WB MO St Rt 6 in Kirksville.