Missouri State Route 81 is a north-south in Northeastern Lewis County. It runs from Missouri State Route 16, near Canton, north to the Clark/Lewis County Line, near Saint Patrick. MO St Rt 81 does not pass through any towns in Lewis County. MO St Rt 81 is not multi-plexed in Lewis County. MO St Rt 81 intersects the following highways Lewis County. Missouri State Route 16, near Canton. Missouri Secondary State Route E, near Saint Patrick.
