U.S. Federal Route 54 is the main north-south highway in Callaway County. It runs the length of the county. This goes from the Callaway/Cole County Line, at Jefferson City, to the Audrain/Callaway County Line, near Auxvasse. U.S. Rt. 54 passes through the following towns in Callaway County. Jefferson City
Holts Summit
Lake Mykee New Bloomfield
Fulton
Kingdom City
Auxvasse U.S. Rt. 54 is multi-plexed in Callaway County. U.S. Rt. 63, at Jefferson City.
Branches of U.S. Rt. 54 in Callaway County. EB U.S. Rt. 54 near Auxvasse. EB U.S. Rt. 54 north of Kingdom City. A BGS on WB I-70/U.S. Rt. 40. NB U.S. Rt. 54 north of Fulton. NB U.S. Rt. 54 north of MO Sec St Rt F in Fulton. A junction marker on EB MO Sec St Rt F. A BGS on EB MO Sec St Rt F. NB U.S. Rt. 54 north of BUSN U.S. Rt. 54/MO Sec St Rt H in Fulton. A junction marker on SB BUSN U.S. Rt. 54. EB U.S. Rt. 54 south of New Bloomfield. EB U.S. Rt. 54 near Lake Mykee. EB U.S. Rt. 54 in Holts Summit. A BGS in Holts Summit. A BGS on SB U.S. Rt. 63. A BGS on SB U.S. Rt. 63. A BGS on SB U.S. Rt. 63. EB U.S. Rt. 54/NB U.S. Rt. 63 at the U.S. Rt. 54/63; MO St Rt 94 interchange. A set of BGS's on EB U.S. Rt. 54/NB U.S. Rt. 63. WB U.S. Rt. 54/SB U.S. Rt. 63 near the Missouri River. WB U.S. Rt. 54/SB U.S. Rt. 63 on the NB approach to the Missouri River Bridge. WB U.S. Rt. 54/SB U.S. Rt. 63 at the truss to the Missouri River Bridge. WB U.S. Rt. 54/SB U.S. Rt. 63 crosssing the Missouri River. EB U.S. Rt. 54/NB U.S. Rt. 63 crossing the Missouri River. EB U.S. Rt. 54/NB U.S. Rt. 63 on the northside of the Missouri River.