U.S. Federal Route 54 runs mostly morth-south through Cole County. It is a four-lane expressway through Cole County. U.S. Rt. 54 passes through the following towns in Cole County. Jefferson City
Brazito Hickory Hill U.S. Rt. 54 is multi-plexed in Cole County. U.S. Rt. 63, at Jefferson City.
U.S. Rt. 54 intersects the following highways in Cole County. U.S. Rt. 50, at Jefferson City. U.S. Rt. 63, at Jefferson City.
Missouri Secondary State Route CC, near Jefferson City. Missouri Secondary State Route D, near Brazito. Missouri Secondary State Route E, near Brazito. Missouri State Route 17, near Hickory Hill.
EB U.S. Rt. 54/NB U.S. Rt. 63 at the Missouri River. EB U.S. Rt. 54/NB U.S. Rt. 63 crossing the Missouri River. WB U.S. Rt. 54/SB U.S. Rt. 63 at Mc Carty Street in Jefferson City. A junction marker on WB U.S. Rt. 50/NB U.S. Rt. 63. A BGS on EB U.S. Rt. 50. Another BGS on EB U.S. Rt. 50. A BGS on EB U.S. Rt. 50. A BGS on EB U.S. Rt. 50. EB U.S. Rt. 54 at Jefferson Street in Jefferson City. EB U.S. Rt. 54 at Madison in Jefferson City. A BGS on SB MO Sec St Rt C. A junction marker on NB MO Sec St Rt B. A BGS on SB MO Sec St Rt B. WB U.S. Rt. 54 near MO St Rt 179/MO Sec St Rt B.
