U.S. Federal Route 61 is a north-south highway in Eastern Jefferson County. It runs from the Jefferson/St. Louis County Line, at the Meramec River, to the Jefferson/Ste Genevieve County Line. U.S. Rt. 61 passes through the following towns in Jefferson County. Crystal City
Festus
Herculaneum
Pevely
Barnhart Imperial Arnold
U.S. Rt. 61 is multi-plexed in Jefferson County. BUSN Loop I-55, from Crystal City to near Herculaneum.
U.S. Rt. 67, from Crystal City to the Jefferson/St. Louis County Line.
U.S. Rt. 61 intersects the following highways in Jefferson County. Missouri Secondary State Route T, near Olympian Village. Missouri Secondary State Route AA, near Olympian Village. Interstate 55, near Olympian Village. Missouri Secondary State Route TT, near Olympian Village.