U.S. Federal Route 61 is a north-south highway in Eastern Ralls County. It is a four-lane highway through the county. U.S. Rt. 61 does not pass through any towns in Ralls County. U.S. Rt. 61 is not multi-plexed in Ralls County. U.S. Rt. 61 intersects the following highways in Ralls County. Missouri Secondary State Route FF, near New London.
Branches of U.S. Rt. 61 in Ralls County. NB U.S. Rt. 61 at the Pike/Ralls County Line. NB U.S. Rt. 61 south of BUSN U.S. Rt. 61/MO St Rt 19. NB U.S. Rt. 61 at BUSN U.S. Rt. 61/MO St Rt 19. A junction marker on SB BUSN U.S. Rt. 61. NB U.S. Rt. 61 north of MO St Rt 19. NB U.S. Rt. 61 at MO Sec St Rt A. NB U.S. Rt. 61 north of New London. NB U.S. Rt. 61 south of Hannibal. NB U.S. Rt. 61 near the Marion/Ralls County Line.