U.S. Federal Route 22 is an east-west highway Essex County. It runs from Interstate 78, to the Essex/Union County Line. The entire route in Essex County is near Newark. U.S. Rt. 22 passes through the following towns in Essex County. Newark U.S. Rt. 22 is not multi-plexed in Essex County. U.S. Rt. 22 intersects the following highways in Essex County. Interstate 78, at Newark. U.S. Rt. 1, at Newark. U.S. Rt. 9, at Newark. New Jersey State Route 21, at Newark. New Jersey State Route 27, at Newark.