New York State Route 16 is a north-south highway in Western Erie County. It runs from the Cattaraugus/Erie County Line to New York State Route 5, in Buffalo. NY St Rt 16 passes through the following towns in Erie County. Chaffee Protection Holland South Wales East Aurora Spring Brook West Seneca Buffalo
NY St Rt 16 is multi-plexed in Erie County. New York State Route 39 from the Chattaraugus/Erie County Line to near Arcade. New York State Route 400, near East Aurora. U.S. Rt. 20A, near East Aurora. New York State Route 78, from East Aurora to West Seneca. NY St Rt 16 intersects the following highways in Erie County. New York State Route 39, near Arcade. New York State Route 400, near South Wales. New York State Route 400, near East Aurora. U.S. Rt. 20A, at East Aurora. New York State Route 78, at East Aurora. U.S. Rt. 20A, near East Aurora. U.S. Rt. 20, near Spring Brook. New York State Route 78, near Spring Brook. New York State Route 277, near West Seneca. Interstate 90, (New York State Thruway) at West Seneca. New York State Route 400, at West Seneca. New York State Route 240, at Weset Seneca. U.S. Rt. 62, at Buffalo. Interstate 190, at Buffalo. New York State Route 5, at Buffalo.
