New York State Route 5 runs east-west across Erie County. This enters Erie County, near Irving, and heads north across the Skyway into Downtown Buffalo. In Buffalo, this highway heads east-west north of Interstate 90/New York State Thruway as it heads to Genessee County. NY St Rt 5 passes through the following towns in Erie County. Irving Farnham Lake Erie Beach Evans Center North Lake View Wanakah Mt. Vernon Athol Springs Woodlawn Beach Buffalo
Williamsville Clarence Center NY St Rt 5 is multi-plexed in Erie County. U.S. Rt. 20, near Irving. NY St Rt 5 intersects the following highways in Erie County. U.S. Rt. 20, near Hanover. New York State Route 438, near Irving. New York State Route 249, near Angola. New York State Route 75, at Althol Springs. New York State Route 179, near Woodlawn Beach. Interstate 190, (Niagara Thruway) at Buffalo. New York State Route 198, at Buffalo. U.S. Rt. 62, at Buffalo. New York State Route 240, at Amherst. Interstate 290, at Amherst. New York State Route 277, at Williamsville. New York State Route 78, at Amherst. New York State Route 324, at Clarence. New York State Route 93, at Newstead.
