New York State Route 354 is an east-west highway in Erie County. It runs from New York State Route 5, in Buffalo to the Erie/Wyoming County Line. NY St Rt 354 passes through the following towns in Erie County. Buffalo
West Seneca Marilla NY St Rt 354 is not multi-plexed in Erie County. NY St Rt 354 crosses the following highways in Erie County. New York State Route 5, at Buffalo. U.S. Rt. 62, at Buffalo. Interstate 190, at Buffalo. Interstate 90, (New York State Thruway), at West Seneca. (NO Interchange) New York State Route 240, at West Seneca. New York State Route 277, near West Seneca. U.S. Rt. 20, near West Seneca. New York State Route 78, near West Seneca.
