New York State Route 78 is a north-south highway in Central Erie County. It runs from the Eire/Niagara County Line south to the Eire/Wyoming County Line. NY St Rt 78 passes through the following towns in Eire County. Swormville East Amherst Bowmansville Depew Spring Brook East Aurora Wales Center NY St Rt 78 is multi-plexed in Erie County. U.S. Rt. 20, from near Depew to near Spring Brook. New York State Route 16, from near Spring Brook to East Aurora. U.S. Rt. 20A, from near East Aurora to Wales Center. NY St Rt 78 intersects the following highways in Erie County. New York State Route 263, near Pendleton. New York State Route 324, near Amherst. New York State Route 5, near Amherst. Interstate 90, (New York State Thruway) near Amherst. New York State Route 33, near Bowmansville. U.S. Rt. 20, near Depew. New York State Route 130, near Depew. New York State Route 354, near Cheektowaga. New York State Route 400, near Elma. U.S. Rt. 20, near Spring Brook. New York Staet Route 16, near Spring Brook. U.S. Rt. 20A, near East Aurora. New York State Route 16, at East Aurora. New York State Route 400, at East Aurora. U.S. Rt. 20A, at Wales Center.
