U.S. Federal Route 129 is a north-south highway in Cherokee County. This is one of the main highways through out the county. Through the center of the county, this route is a multi-lane divided highway. U.S. Rt. 129 passes through the following towns in Cherokee County. Murphy
U.S. Rt. 129 is multi-plexed in Cherokee County. U.S. Rt. 64, from near Ranger to near Murphy.
U.S. Rt. 19, from the Georgia/North Carolina State Line to the Macon/Cherokee County Line.
U.S. Rt. 74, near Ranger to the Macon/Cherokee County Line.