U.S. Federal Route 19 is a north-south highway in Cherokee County. This is one of the main highways through out the county. Through the center of the county, this route is a multi-lane divided highway. U.S. Rt. 19 passes through the following towns in Cherokee County. Murphy
Andrews
Topton
U.S. Rt. 19 is multi-plexed in Cherokee County. U.S. Rt. 64, from near Ranger to near Murphy.
U.S. Rt. 129, from the Georgia/North Carolina State Line to the Macon/Cherokee County Line.
U.S. Rt. 74, near Ranger to the Macon/Cherokee County Line.
Branches of U.S. Rt. 19 in Cherokee County. A guide marker on EB U.S. Rt. 64/74. EB U.S. Rt. 64/74, NB U.S. Rt. 19/129 near Murphy. EB U.S. Rt. 64/74, NB U.S. Rt. 19/129 at Murphy. EB U.S. Rt. 74/NB U.S. Rt. 19/129 near Marble. EB U.S. Rt. 74, NB U.S. Rt. 19/129 at Andrews. EB U.S. Rt. 74, NB U.S. Rt. 19/129 near Topton.