Ohio State Route 46 is a north-south highway in Cnetral Ashtabula County. It runs from Ohio State Route 11 north of Jefferson to Ashtabula/Trumbull County Line. OH St Rt 46 passes through the following towns in Ashtabula County. Jefferson South New Lyme Colebrook OH St Rt 46 is multi-plexed in Ashtabula County. Ohio State Route 307, at Jefferson. OH St Rt 46 intersects the following highways in Ashtabula County. Ohio State Route 11, near Jefferson. Ohio State Route 167, at Jefferson. Ohio State Route 307, at Jefferson. Ohio State Route 307, at Jefferson. U.S. Rt. 6, near South New Lyme. U.S. Rt. 322, at Colebrook.
