U.S. Federal Route 22 is a east-west highway in Central Muskingum County. It runs from the Perry/Muskingum County Line, near Mt. Perry, to the Muskingum/Guernsey County Line, near New Concord. U.S. Rt. 22 passes through the following towns in Muskingum County. East Fultonham White Cottage South Zanesville Zanesville Pleasant Grove Norwich New Concord U.S. Rt. 22 is multi-plexed in Muskingum County. Ohio State Route 93, from near White Cottage, to near Pleasant Grove. U.S. Rt. 40, from Zanesville to the Muskingum/Guernsey County Line.