U.S. Federal Route 412 runs east-west across much of Noble County. Through Noble County, most of this highway runs on the Cimarron Turnpike. This highway is multiple lanes through the entire county. U.S. Rt. 412 passes through the county twice. U.S. Rt. 412 does not pass through any towns in Noble County. U.S. Rt. 412 is multi-plexed in Nobel County. U.S. Rt. 64, from near Ceres to the Garfield/Noble County Line. U.S. Rt. 412 intersects the following highways in Nobel County. U.S. Rt. 64, near Lela. U.S. Rt. 177, near Morrison. U.S. Rt. 77, near Red Rock. Interstate 35, near Ceres. U.S. Rt. 64, near Ceres. Cimarron Turnpike, near Ceres.