Pennsylvania State Route 21 is tha main east-west highway in Greene County. It goes from the Ohio/Pennsylvania State Line, near McCracken, to the Greene/Fayette County Line, near Paisley. PA St Rt 21 passes through the following towns in Greene County. Wind Ridge Graysville Rutan Rogersville Waynesburg Khedive PA St Rt 21 is multi-plexed in Greene County. Pennsylvania State Route 18, from near Rogersville to Waynesburg. U.S. Rt. 19, near Waynesburg. PA St Rt 21 intersects the following highways in Greene County. Pennsylvania State Route 18, near Rogersville. Pennsylvania State Route 18, at Waynesburg. U.S. Rt. 19, at Waynesburg. Pennsylvania State Route 218, at Waynesburg. U.S. Rt. 19, near Waynesburg. Pennsylvania State Route 188, near Waynesburg. Interstate 79, near Waynesburg. Pennsyvlania State Route 88, near Paisley.
