U.S. Federal Route 19 is a north-south highway in Central Greene County. It runs along the Interstate 79 corridor. U.S. Rt. 19 passes through the following towns in Greene County. Mount Morris Kirby Waynesburg Ruff Creek U.S. Rt. 19 is multi-plexed in Greene County. Pennsylvania State Route 21, near Waynesburg. U.S. Rt. 19 intersects the following highways in Green County. Pennsylvania State Route 21, near Wyanesburg. Pennsylvania State Route 188, near Wyanesburg. Pennsylvania State Route 21, at Waynesburg. Pennsylvania State Route 218, at Waynesburg. Pennsylvania State Route 221, at Ruff Creek.
