Pennsylvania State Route 221 is a north-south highway in North-Central Greene County. It goes from Pennsylvania State Route 188, near Lippincott, to the Greene/Washington County Line, near Dunns Station. PA St Rt 221 passes through the following towns in Greene County. Lippincott Ruff Creek PA St Rt 221 is not multi-plexed in Greene County. PA St Rt 221 intersects the following highways in Greene County. Pennsylvania State Route 188, ear Lippincott. Interstate 79, near Ruff Creek. U.S. Rt. 19, at Ruff Creek.
