Pennsylvania State Route 416 is a north-south highway in Southwestern Franklin County. It runs from the Pennsylvania/Maryland State Line, near Cearfoss, Maryland, to U.S. Rt. 30, near St. Thomas. PA St Rt 416 passes through the following towns in Franklin County. Welsh Run Mercersburg
A junction marker on WB PA St Rt 16. A guide marker on WB PA St Rt 16. WB PA St Rt 16/NB PA St Rt 416 east of Mercersburg. WB PA St Rt 16; NB PA St Rt 75/416 west of Constitution. WB PA St Rt 16; NB PA St Rt 75/416 north of Buchanan Trail West. WB PA St Rt 16; NB PA St Rt 75/416 south of Oregon.
