Pennsylvania State Route 645 is a north-south highway in Eastern Lebanon County County. It runs from U.S. Rt. 422, in Myerstown, to the Lebanon/Berks County Line, near Mt Aetna. PA St Rt 645 passes through the following town in Lebanon County. Myerstown PA St Rt 645 is not multi-plexed in Lebanon County. PA St Rt 645 intersects the following highway in Lebanon County. U.S. Rt. 422, at Myerstown.