U.S. Federal Route 222 is an east-west highway in Lehigh County. It runs from the Lehigh/Berks County Line, near Maxatawny, to Interstate 78; Pennsylvania State Route 222/309, near Wescosville. U.S. Rt. 222 passes through the following towns in Lehigh County. Breinigsville Trexlertown Wescosville U.S. Rt. 222 is multi-plexed in Lehigh County. Pennsylvania State Route 100, at Trexlertown. U.S. Rt. 222 crosses the following highways in Lehigh County. Pennsylvania State Route 863, near Maxatawny. Pennsylvania State Route 100, at Trexlertown. Pennsylvania State Route 100, at Trexlertown. Interstate 476, (Pennsylvania Turnpike-NE Ext),ner Wescosville. (NO Interchange) Interstate 78, at Wescosville. Pennsylvania State Route 222, at Wescosville. Pennsylvania State Route 309, at Wescoville.
A BGS on SB PA St Rt 100. NB U.S. Rt. 222 at I-78/PA St Rt 309.
