U.S. Federal Route 22 runs east-west across Central Lehigh County. It runs from the Lehigh/Berks County Line, near New Smithville, to the Lehigh/Northampton County Line, at Bethlehem. U.S. Rt. 22 passes through the following towns in Lehigh County. New Smithville Fogelsville Weenersville Allentown Fullerton Bethlehem U.S. Rt. 22 is multi-plexed in Lehigh County. Interstate 78, from the Lehigh/Berks County Line to near Weenersville. U.S. Rt. 22 intersects the following highways in Lehigh County. Pennsylvania State Route 863, near New Smithville. Pennsylvania State Route 100, at Fogelsville. Interstate 78, near Fogelsville. Interstate 476, (Pennsylvania Turnpike-NE Ext) near Weenersville. Pennsylvania State Route 309, at Weenersville. Pennyslvania State Route 145, at Allentown. Pennsylvania State Route 987, near Allentown. Pennsylvania State Route 387, near Bethlehem.
A BGS on SB PA St Rt 100. A BGS on SB I-476. WB U.S. Rt. 22 west of PA St Rt 309. WB U.S. Rt. 22 at PA St Rt 309. WB U.S. Rt. 22 west of PA St Rt 145. A BGS on NB PA St Rt 145.
