South Carolina State Route 101 is a north-south highway in Southwestern Spartanburg County. It runs from the Laurens/Spartanburg County Line, north of Youngs, to the Greenville/Spartanburg County Line, at Greer. SC St Rt 101 passes through the following towns in Spartanburg County. Woodruff Cashville Greer SC St Rt 101 is multi-plexed in Spartanburg County. U.S. Rt. 221, at Woodruff. South Carolina State Route 146, near Woodruff. SC St Rt 101 intersects the following highways in Spartanburg County. U.S. Rt. 221, at Woodruff. South Carolina State Route 146, at Woodruff. U.S. Rt. 221, at Woodruff. South Caroling State Route 418, near Woodruff. South Carolina State Route 146, near Cashville. South Carolina State Route 417, at Cashville. South Carolina State Route 296, near Reidville. Interstate 85, near Greer. South Carolina State Route 80, at Greer.
