U.S. Federal Route 221, Spartanburg County, South Carolina

Roads of the Mid-South & West > Highways of the State of South Carolina > U.S. Federal Route 221, South Carolina > U.S. Federal Route 221; Spartanburg County, South Carolina

U.S. Federal Route 221
Spartanburg County

U.S. Federal Route 221 is a north-south highway in Spartanburg County. It runs from the Spartanburg/Laurens County Line, near Enoree, to the Spartanburg/Cherokee County Line, near Chesnee.

U.S. Rt. 221 passes through the following towns in Spartanburg County.
Enoree
Woodruff
Moore
Roebuck
Spartanburg

Cherokee Springs
Mayo
Chesnee

U.S. Rt. 221 is multi-plexed in Spartanburg County.
South Carolina State Route 92, near Enoree.
South Carolina State Route 146, at Woodruff.
South Carolina State Route 101, at Woodruff.
South Carolina State Route 56, at Spartanburg.

U.S. Rt. 221 intersects the following highways in Spartanburg County.
South Carolina State Route 92, at Enoree.
Connector South Carolina State Route 92, at Enroee.
South Carolina State Route 146, at Woodruff.
South Carolina State Route 101, at Woodruff.
South Carolina State Route 101, at Woodruff.
South Carolina State Route 146, at Woodruff.
South Carolina State Route 290, at Moore.
Interstate 26, at Roebuck.
South Carolina State Route 215, at Roebuck.
South Carolina State Route 295, at Roebuck.
South Carolina State Route 56, at Spartanburg.

U.S. Rt. 29, at Spartanburg.
South Carolina State Route 56, at Spartanburg.
South Carolina State Route 296, at Spartanburg.
Connector U.S. Rt. 176, at Spartanburg.
Interstate 585, at Spartanburg.
U.S. Rt. 176, at Spartanburg.
South Carolina State Route 9, at Spartanburg.
Interstate 85, at Spartanburg.
ALT U.S. Rt. 221, at Chesnee.
South Carolina State Route 11, at Spartanburg.

Branches of U.S. Rt. 221 in Spartanburg County.

SB U.S. Rt. 221/SC St Rt 56 south of St. John Street.

A junction marker on NB U.S. Rt. 29.

A junction marker on EB Danial Morgan Ave.

A BGS on NB I-585/U.S. Rt. 176/SC St Rt 9.

25 December 2022