U.S. Federal Route 123 runs east-west across West-Central Greenville County. It runs from the Pickens/Greenville County Line, west of Greenville, to BUSN Spur Interstate 385, at Greenville. U.S. Rt. 123 passes through the following town in Greenville County. Greenville
U.S. Rt. 123 is not multi-plexed in Greenville County. U.S. Rt. 123 intersects the following highways in Greenville County. U.S. Rt. 25, at Greenville. South Carolina State Route 124, at Greenville.
NB U.S. Rt. 123 at the Greenville/Pickens County Line. NB U.S. Rt. 123 near Rison Road. NB U.S. Rt. 123 east of U.S. Rt. 25. NB U.S. Rt. 123 near Brushy Creek. NB U.S. Rt. 123 at SC St Rt 124. NB U.S. Rt. 123 near Westfield Street. NB U.S. Rt. 123 near Reedy River. NB U.S. Rt. 123 south of Church Street. A guide marker on U.S. Rt. 29.
