U.S. Federal Route 25 is a north-south highway in Western Greenville County. It runs from the Greenville/Laurens County Line, near Princeton, to the North Carolina/South Carolina State Line, south of Tuxedo, North Carolina. U.S. Rt. 25 passes through the following towns in Greenville County. McKelvey Crossroads Ware Place Woodville Greenville
White Horse Parker Travelers Rest U.S. Rt. 25 is multi-plexed in Greenville County. U.S. Rt. 76, near Princeton. U.S. Rt. 276, near Travelers Rest. South Carolina State Route 414, near Slater-Marietta. U.S. Rt. 25 crosses the following highways in Greenville County. U.S. Rt. 76, near Princeton. U.S. Rt. 76, near Princeton. South Carolina State Route 247, near Ware Place. South Carolina State Route 8, at Ware Place. South Carolina State Route 418, at Ware Place. South Carolina State Route 86, near Piedmont. Interstate 185, at Greenville. South Carolina State Route 291, at Greenville. Interstate 85, at Greenville. South Carolina State Route 20, at Greenville. Interstate 185, at Greenville. (NO Direct Interchange) U.S. Rt. 29, at Greenville. (NO Direct Interchange) South Carolina State Route 81, at Greenville. U.S. Rt. 123, at Greenville. South Carolina State Route 124, at Greenville. South Carolina State Route 253, at Greenville. South Carolina State Route 183, at Greenville. U.S. Rt. 276, at Travelers Rest. U.S. Rt. 276, at Travelers Rest. Connector U.S. Rt. 25, at Travelers Rest. South Carolina State Route 290, near Slater-Marietta. South Carolina State Route 414, near Slater-Marietta. South Carolina State Route 414, near Slater-Marietta. South Carolina State Route 11, near Cleveland.
Branches of U.S. Rt. 25 in Greenville County. A BGS on NB I-85. A BGS on SB I-185/U.S. Rt. 29. A BGS on SB I-185/U.S. Rt. 29. A guide marker on NB U.S. Rt. 123.
