U.S. Federal Route 178 is a north-south highway in Central Pickens County. It runs from the Anderson/Pickens County Line, south of Liberty, to the North Carolina/South Carolina State Line, near Rocky Bottom. U.S. Rt. 178 passes through the following towns in Pickens County. Liberty Pickens Rocky Bottom U.S. Rt. 178 is multi-plexed in Pickens County. South Carolina State Route 183, at Pickens. U.S. Rt. 178 intersects the following highways in Pickens County. South Carolina State Route 135, near Liberty. U.S. Rt. 123, near Liberty. South Carolina State Route 93, at Liberty. South Carolina State Route 183, at Pickens. South Carolina State Route 183, at Pickens. South Carolina State Route 288, near Sunset. South Carolina State Route 11, near Sunset.
