U.S. Federal Route 123 runs east-west across Southern Pickens County. It runs from the Oconee/Pickens County Line, near Clemson, to the Pickens/Greenville, near Parker. U.S. Rt. 123 passes through the following towns in Pickens County. Clemson Liberty Easley
EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 at the Oconee/Pickens County Line. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 near Keowee Trail. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 east of Stoney Creek Lane. NB U.S. Rt. 123 east of U.S. Rt. 76/SC St Rt 28. NB U.S. Rt. 123 west of SC St Rt 93. NB U.S. Rt. 123 at SC St Rt 93. NB U.S. Rt. 123 east of SC St Rt 93. NB U.S. Rt. 123 east of Clemson. NB U.S. Rt. 123 at Road 18. NB U.S. Rt. 123 east of Road 18. NB U.S. Rt. 123 west of Road 27. NB U.S. Rt. 123 west of U.S. Rt. 178. NB U.S. Rt. 123 at U.S. Rt. 178. NB U.S. Rt. 123 at Cartee Road. NB U.S. Rt. 123 east of Liberty. NB U.S. Rt. 123 west of Easley. NB U.S. Rt. 123 near Ross Ave. A guide marker on NB SC St Rt 135. A guide marker on SB SC St Rt 135. A guide marker on NB SC St Rt 135. NB U.S. Rt. 123 east of SC St Rt 135. NB U.S. Rt. 123 at Pilgrim Drive. NB U.S. Rt. 123 east of Powdersville Road. NB U.S. Rt. 123 east of Prince Perry Road. NB U.S. Rt. 123 west of SC St Rt 153. NB U.S. Rt. 123 at SC St Rt 153. NB U.S. Rt. 123 east of SC St Rt 124. NB U.S. Rt. 123 near Fish Trap Road.