Roads of the Mid-South & West > Highways of the State of South Carolina > U.S. Federal Route 221, South Carolina

U.S. Federal Route 221

U.S. Federal Route 221 is a north-south highway in Northwestern South Carolina. It runs from the Georgia/South Carolina State Line, near Modoc, to the North Carolina/South Carolina State Line, near Chesnee. Info on U.S. Rt. 221 is broken down by county below.

McCormick County Greenwood County Laurens County
Spartanburg County Cherokee County

25 December 2022