Roads of the Mid-South & West > Highways of the State of South Carolina > U.S. Federal Route 221, South Carolina
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U.S. Federal Route 221 is a north-south highway in Northwestern South Carolina. It runs from the Georgia/South Carolina State Line, near Modoc, to the North Carolina/South Carolina State Line, near Chesnee. Info on U.S. Rt. 221 is broken down by county below.
McCormick County Greenwood County Laurens County
Spartanburg County Cherokee County
25 December 2022