West Virginia State Route 2 is the main north-south highway in Western Brooke County. It runs from the Brooke/Hancock County Line, in Weirton, to the Brooke/Ohio County Line, near Windsor Heights. WV St Rt 2 passes through the following towns in Brooke County. Weirton
Follansbee Wellsburg WV St Rt 2 is multi-plexed in Brooke County. U.S. Rt. 22, at Weirton.
WV St Rt 2 intersects the following highways in Brooke County. U.S. Rt. 22, at Weirton.
SB WV St Rt 2 near WV St Rt 27. A BGS on EB U.S. Rt. 22. A BGS on WB U.S. Rt. 22/SB WV St Rt 2. A BGS on EB U.S. Rt. 22. EB U.S. Rt. 22/NB WV St Rt 2 east of west U.S. Rt. 22. EB U.S. Rt. 22/NB WV St Rt 2 at east U.S. Rt. 22. A guide marker on NB WV St Rt 2. SB WV St Rt 2 at east U.S. Rt. 2. NB WV St Rt 2 north of east U.S. Rt. 22. A guide marker on WV Sec St Rt 507. NB WV St Rt 2 near Heaslett Ave.
