West Virginia State Route 2 is the main north-south highway in Western Ohio County. Two portions of this highway runs along a expressway. WV St Rt 2 passes through the following town in Ohio County. Wheeling WV St Rt 2 is multi-plexed in Ohio County. U.S. Rt. 250, at from the Ohio/Marshall County Line to Wheeling. U.S. Rt. 40, at Wheeling. WV St Rt 2 intersects the following highways in Ohio County. Interstate 470, at Wheeling. U.S. Rt. 250, at Wheeling.
NB U.S. Rt. 250/WV St Rt 2 at the Ohio/Marshall County Line. NB U.S. Rt. 250/WV St Rt 2 near 41st Street. NB U.S. Rt. 250/WV St Rt 2 south of I-470. A BGS on NB U.S. Rt. 250/WV St Rt 2. NB U.S. Rt. 250/WV St Rt 2 at I-470. A BGS on EB I-470. This is actually in Ohio. NB U.S. Rt. 250/WV St Rt 2 north I-470. NB U.S. Rt. 250/WV St Rt 2 south of Wheeling Creek. NB U.S. Rt. 250/WV St Rt 2 at north U.S. Rt. 250. NB WV St Rt 2 at U.S. Rt. 250. NB WV St Rt 2 at 18th. A BGS on WB I-70. A BGS on EB I-70. A guide marker on EB U.S. Rt. 40/SB WV St Rt 2. A BGS on EB U.S. Rt. 40/SB WV St Rt 2. EB U.S. Rt. 40/NB WV St Rt 2 at I-70. A BGS on EB U.S. Rt. 40/NB WV St Rt 2. SB WV St Rt 2 at I-70/U.S. Rt. 250.
