U.S. Federal Route 150 is the main surface alternative to Interstate 74 in Knox County. This is the only numbered highway to run into Galesburg. U.S. Rt. 150 passes through the following towns in Knox County. Galesburg
EB U.S. Rt. 150 at the Knox/Henry County Line. EB U.S. Rt. 150 north of Galesburg. A BGS on EB U.S. Rt. 34/NB IL St Rt 110. WB U.S. Rt. 150 at one of the BNSF crossings in Galesburg. EB U.S. Rt. 150 east of Downtown Galesburg. WB U.S. Rt. 150 west of Knoxville. A BGS on EB I-74. A BGS on WB I-74. WB U.S. Rt. 150 west of I-74/IL St Rt 97. WB U.S. Rt. 150 near Spoon River. WB U.S. Rt. 150 west of IL St Rt 180. WB U.S. Rt. 150 at the Peoria/Knox County Line.