U.S. Federal Route 45 runs north-south through the center of Champaign County. This is the main north-south surface route through the Champaign-Urbana Metro area. U.S. Rt. 45 passes through the following towns in Champiagn County. Rantoul
U.S.Rt. 45 is multi-plexed in Champaign County. U.S. Rt. 150, at Urbana.
U.S. Rt. 45 intersects the following highways in Champaign County. U.S. Rt. 136, at Rantoul.