U.S. Federal Route 45 is the main north-south surface highway in western Coles County. U.S. Rt. 45 passes through the following towns in Coles County. Dorans Mattoon
U.S. Rt. 45 is multi-plexed in Coles County. Illinois State Route 121, from Mattoon to the Coles/Cumberland County Line.
SB U.S. Rt. 45 at the Coles/Douglas County Line. NB U.S. Rt. 45 near Humboldt. A Coles County mile marker. SB U.S. Rt. 45 north of Mattoon. SB U.S. Rt. 45 north of Coles County Highway 18. SB U.S. Rt. 45 on the northside of Mattoon. SB U.S. Rt. 45/EB IL St Rt 121 in Mattoon. SB U.S. Rt. 45/EB IL St Rt 121 north of IL St Rt 16. BGS on SB I-57. A BGS on SB I-57.