U.S. Federal Route 45 is the main north-south surface highway in western Coles County. U.S. Rt. 45 passes through the following towns in Coles County. Dorans Mattoon
U.S. Rt. 45 is multi-plexed in Coles County. Illinois State Route 121, from Mattoon to the Coles/Cumberland County Line.
SB U.S. Rt. 45 at the Coles/Douglas County Line. NB U.S. Rt. 45 near Humboldt. A Coles County mile marker. SB U.S. Rt. 45 north of Mattoon. SB U.S. Rt. 45 north of Coles County Highway 18. SB U.S. Rt. 45 on the northside of Mattoon. SB U.S. Rt. 45/EB IL St Rt 121 in Mattoon. SB U.S. Rt. 45/EB IL St Rt 121 north of IL St Rt 16. NB U.S. Rt. 45/EB IL St Rt 121 south of Charleston in Mattoon. NB U.S. Rt. 45/EB IL St Rt 121 near Lafayette in Mattoon. NB U.S. Rt. 45/EB IL St Rt 121 south of Rudy in Mattoon. NB U.S. Rt. 45/EB IL St Rt 121 at 19th in Mattoon. NB U.S. Rt. 45/EB IL St Rt 121 north of I-57. BGS on SB I-57. A BGS on SB I-57. A BGS on SB I-57. NB U.S. Rt. 45/EB IL St Rt 121 at I-57. NB U.S. Rt. 45/EB IL St Rt 121 south of I-57. A Coles County mile marker. NB U.S. Rt. 45/IL St Rt 121 at the Coles/Cumberland County Line.
