U.S. Federal Route 45 is the main north-south surface highway in western Coles County. U.S. Rt. 45 passes through the following towns in Coles County. Dorans Mattoon U.S. Rt. 45 is multi-plexed in Coles County. Illinois State Route 121, from Mattoon to the Coles/Cumberland County Line.
SB U.S. Rt. 45 at the Coles/Douglas County Line. NB U.S. Rt. 45 near Humboldt. A Coles County mile marker. SB U.S. Rt. 45/EB IL St Rt 121 in Mattoon. BGS on SB I-57.