U.S. Federal Route 45 is a north-south highway in Cook County. This is one of the longest counties that this highways passes through while in Illinois. It is one of the busiest north-south surface highways in this part of the county. U.S. Rt. 45 passes through the following towns in Cook County. Tinley Park
Orland Hills
Orland Park
Palos Park Willow Springs
Hodgkins Countryside La Grange La Grange Park
Westchester Hillside
Bellwood Melrose Park
Stone Park Franklin Park Schiller Park
Rosemont Des Plaines
Mount Prospect Prospect Heights
Wheeling
U.S. Rt. 45 is multi-plexed in Cook County. U.S. Rt. 12, from near Hickory Hills to Des Plaines.
U.S. Rt. 20, from near Hickory Hills to Stones Park.
NB U.S. Rt. 45/IL St Rt 21 in Wheeling. A junction marker on EB IL St Rt 68. A set of BGS's on EB I-190. EB U.S. Rt. 12/SB U.S. Rt. 45 at O'Hare International Airport. A junction marker on EB IL St Rt 64. A junction marker on EB U.S. Rt. 20. A street sign on a stop light mast in Melrose Park. A BGS on EB I-290. A junction marker on EB IL St Rt 38. EB U.S. Rt. 12/20; SB U.S. Rt. 45 in La Grange Park. A junction marker on EB U.S. Rt. 34. A set of guide markers on EB U.S. Rt. 34. EB U.S. Rt. 12/20; SB U.S. Rt. 45 north of I-55. A BGS on NB I-55. Another BGS on NB I-55. EB U.S. Rt. 12/20; NB U.S. Rt. 45 in Willow Springs. A BGS on IL St Rt 171. EB U.S. Rt. 12/20; SB U.S. Rt. 45 at I-294/IL St Rt 171. NB U.S. Rt. 45 at the Cal-Sag Channel. NB U.S. Rt. 45 north of Southwest Highway. A junction marker on EB U.S. Rt. 6. SB U.S. Rt. 45 at the Cook/Will County Line.