U.S. Federal Route 45 runs north-south in Will County. Much of U.S. Rt. 45 is surrounded by farm land, with the exception of the area around the Will/Cook County Line. U.S. Rt. 45 passes through the following towns in Will County. Mokena
Frankfort
Andres
U.S. Rt. 45 is multi-plexed in Will County. U.S. Rt. 52, from 1 mile south of Andres to the Kankakee/Will County Line.
U.S. Rt. 45 intersects the following highways. Interstate 80, at Mokena. U.S. Rt. 30, at Frankfort.
NB U.S. Rt. 45/WB U.S. Rt. 52 at the Kankakee/Will County Line. Looking north at U.S. Rt. 45/52 at the Will/Kankakee County Line. SB U.S. Rt. 45/EB U.S. Rt. 52 south of Peotone Road. SB U.S. Rt. 45/EB U.S. Rt. 52 at Wilmington-Peotone Road. SB U.S. Rt. 45/EB U.S. Rt. 52 south of U.S. Rt. 52. (December, 2011) SB U.S. Rt. 45/EB U.S. Rt. 52 south of U.S. Rt. 52. (September, 2015) NB U.S. Rt. 45/WB U.S. Rt. 52 near Wilton Center. NB U.S. Rt. 45/EB U.S. Rt. 52 south of North Peotone Road. A junction marker on EB U.S. Rt. 52. A guide sign on EB U.S. Rt. 52. SB U.S. Rt. 45 north of west U.S. Rt. 52. NB U.S. Rt. 45 north of U.S. Rt. 52. NB U.S. Rt. 45 north of U.S. Rt. 52. SB U.S. Rt. 45 near Andres. NB U.S. Rt. 45 at Andres. NB U.S. Rt. 45 north of Andres. NB U.S. Rt. 45 south of Manhattan-Monee Road. NB U.S. Rt. 45 at Manhattan-Monee Road. NB U.S. Rt. 45 south of Laraway Road. A guide marker on EB Laraway Road. A guide marker on EB Laraway Road. NB U.S. Rt. 45 at the CN underpass. SB U.S. Rt. 45 in Frankfort. Ahead in the picture is a pedestrian walkway. NB U.S. Rt. 45 south of U.S. Rt. 30. A junction marker on EB U.S. Rt. 30. A street sign at U.S. Rt. 30. NB U.S. Rt. 45 at Colorado in Frankfort. NB U.S. Rt. 45 near 195th. NB U.S. Rt. 45 at I-80. A mileage chart on EB I-80 east of I-355. BGS on EB I-80. A BGS on EB I-80. A BGS on EB I-80. A BGS on WB I-80. SB U.S. Rt. 45 south of the Cook/Will County Line. SB U.S. Rt. 45 at the Will/Cook County Line.
