U.S. Federal Route 40 runs east-west across the center of Wayne County. This runs, for the most part, south of Interstate 70. U.S. Rt. 40 passes through the following towns in Wayne County. Dublin Mt. Auburn Cambridge City
East Germantown Pennville Centerville
U.S. Rt. 40 is not multi-plexed in Wayne County. U.S. Rt. 40 intersects the following highways in Wayne County. Indiana State Route 1, at Cambridge City.