U.S. Federal Route 421 runs from the northwest to the southeast portions of Shelby County. It goes from the Marion/Shelby County Line, near Pleasant View, to the Rush/Shelby County Line, near Middletown. U.S. Rt. 421 passes through the following town in Shelby County. Shelbyville U.S. Rt. 421 is multi-plexed in Shelby County. Interstate 74, throughout the entire length of Shelby County.
EB I-74/SB U.S. Rt. 421 at the Marion/Shelby County Line. A BGS near Pleasant View. This sign has an error. The IN shield should be a U.S. shield. WB I-74/NB U.S. Rt. 421 west of Fairland. EB I-74/SB U.S. Rt. 421 near Fairland. EB I-74/SB U.S. Rt. 421 east of Fairland. WB I-74/NB U.S. Rt. 421 west of IN St Rt 9. EB I-74/SB U.S. Rt. 421 at IN St Rt 9. EB I-74; SB U.S. Rt. 421/TRUCK IN St Rt 9 east of IN St Rt 9. EB I-74; SB U.S. Rt. 421/TRUCK IN St Rt 9 west of IN St Rt 44. EB I-74/SB U.S. Rt. 421 at IN St Rt 44. EB I-74/SB U.S. Rt. 421 east of Shelbyville. WB I-74/NB U.S. Rt. 421 east of IN St Rt 44. WB I-74/NB U.S. Rt. 421 west of IN St Rt 244. EB I-74/SB U.S. Rt. 421 east of IN St Rt 244. EB I-74/SB U.S. Rt. 421 near Walron. WB I-74/NB U.S. Rt. 421 at the Decatur/Shelby County Line.
