U.S. Federal Route 421 runs from the northwest to the southeast portions of Shelby County. It goes from the Marion/Shelby County Line, near Pleasant View, to the Rush/Shelby County Line, near Middletown. U.S. Rt. 421 passes through the following town in Shelby County. Shelbyville U.S. Rt. 421 is multi-plexed in Shelby County. Interstate 74, throughout the entire length of Shelby County.