Iowa State Route 27 is a north-south expressway in Central Lee County. This is the southern most county in the State of Iowa that IA St Rt 27 passes through. It runs from the Iowa/Missouri State Line, at Saint Francisville to the Lee/Henry County Line, near Houghton. IA St Rt 27 passes through the following towns in Lee County. Argyle Donnellson
IA St Rt 27 is multi-plexed in Lee County. U.S. Rt. 218, from near Donnellson to the Lee/Henry County Line. IA St Rt 27 intersects the following highways in Lee County. U.S. Rt. 218, near Donnellson. Iowa State Route 2, at Donnellson.
