U.S. Federal Route 218 runs north-south across Central and Southeastern Lee County. This is the southern most county that the highway passes through in the State of Iowa. It is also the southern end point for the highway itself. It runs from a junction with U.S. Rt. 136/BUSN U.S. Rt. 61, in Downtown Keokuk, to the Lee/Henry County Line, near Houghton. U.S. Rt. 218 passes through the following towns in Lee County. Keokuk
Donnellson
U.S. Rt. 218 is multi-plexed in Lee County. BUSN U.S. Rt. 61, at Keokuk.
U.S. Rt. 61, from near Keokuk to near Montrose. Iowa State Route 27, from near Donnellson to the Lee/Henry County Line. U.S. Rt. 218 intersects the following highways in Lee County. U.S. Rt. 136, at Keokuk.
A BGS on NB U.S. Rt. 61 in Missouri. A set of guide markers on NB U.S. Rt. 61/EB U.S. Rt. 136. A junction marker on EB U.S. Rt. 136/NB BUSN U.S. Rt. 61. A junction marker on WB IA St Rt 2. A guide marker on SB U.S. Rt. 61.
