U.S. Federal Route 61 is the main north-south highway in Eastern Lee County. This runs along the Mississippi River banks. It connects Fourt Madison and Keokuk to each other. U.S. Rt. 61 passes through the following towns in Lee County. Wever Fort Madison
Keokuk
U.S. Rt. 61 is multi-plexed in Lee County. Iowa State Route 2, at Fort Madison.
Branches of U.S. Rt. 61 in Lee County. SB U.S. Rt. 61 south of the Des Moines/Lee County Line. SB U.S. Rt. 61 near Fort Madison. Looking south along the new alignment of U.S. Rt. 61 on the northside of Fort Madison. (September, 2011) SB U.S. Rt. 61 at Fort Madison. SB U.S. Rt. 61/WB IA St Rt 2 in Fort Madison. A BGS on SB U.S. Rt. 61/WB IA St Rt 2. SB U.S. Rt. 61/218 at Keokuk. A junction marker on NB U.S. Rt. 218/BUSN U.S. Rt. 61. NB U.S. Rt. 61/NB U.S. Rt. 136 at the Iowa State Line. NB U.S. Rt. 61/NB U.S. Rt. 136 at the Iowa/Missouri State Line.