U.S. Federal Route 50 runs along the interstate system in it's entire time in Johnson County. It runs along Interstate 35 from the Johnson/Miami County Line to Interstate 435. From Interstate 35 it follows Interstate 435 to the Kansas/Missouri State Line. U.S. Rt. 50 passes through the following towns in Johnson County. Gardner Olathe
Overland Park Leawood U.S. Rt. 50 is multi-plexed in Johnson County. Interstate 35, from the Johnson/Miami County Line to Lenexa. U.S. Rt. 56, from Gardner to Lenexa. U.S. Rt. 169, from Olathe to Lenexa.