Kentucky State Route 22 runs east-west in Northeastern Metro-Louisville. It runs from the Metro-Louisville/Oldham County Line to U.S. Rt. 42, in Northfield. KY St Rt 22 passes through the following towns in Metro-Louisville. Louisville
KY St Rt 22 is not multi-plexed in Metro-Louisville. KY St Rt 22 intersects the following highways in Metro-Louisville. Kentucky Secondary State Route 1694, at Louisville. Interstate 265, at Louisville. Kentucky State Route 841, at Louisville. Kentucky Secondary State Route 1747, at Louisville. Connector Kentucky State Route 22, at Louisville. Kentucky Secondary State Route 2050, at Louisville. U.S. Rt. 42, at Louisville.
Branches of KY St Rt 22 in Metro-Louisville. A BGS on WB I-264. A BGS on NB I-265/KY St Rt 841. A BGS on NB I-265/KY St Rt 841.
