U.S. Federal Route 25 is a north-south highway in Fayette County. It runs from the Fayette/Scott County Line, near New Zion, to the Fayette/Madison County Line, near Spears. U.S. Rt. 25 passes through the following town in Fayette County. Lexington
SB U.S. Rt. 25 north of KY Sec St Rt 1963. SB U.S. Rt. 25 at KY Sec St Rt 1963. A BGS on SB I-75. A BGS on NB I-75. A BGS on WB KY St Rt 4. A BGS on WB KY St Rt 4.