Roads of the Mid-South & West > Highways of the Commonwealth of Kentucky > U.S. Highways of the Commonwealth of Kentucky > U.S. Federal Route 421, Kentucky > U.S. Federal Route 421; Fayette County, Kentucky

U.S. Federal Route 421 Fayette County

U.S. Federal Route 421 runs north-south in Central Fayette County. It runs from the Fayette/Scott County Line, near Midway, to the Fayette/Madison County Line, near Spears.

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U.S. Rt. 421 passes through the following town in Fayette County.
Lexington

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U.S. Rt. 421 is multi-plexed in Fayette County.
U.S. Rt. 25, at Lexington.
U.S. Rt. 60, at Lexington.
Interstate 75, near Spears.

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U.S. Rt. 421 crosses the following highways in Fayette County.
Kentucky Secondary State Route 1977, near Yarnallton.
BY-PASS U.S. Rt. 421, at Lexington.
Kentucky State Route 4, at Lexington.
U.S. Rt. 25, at Lexington.
Kentucky State Route 922, at Lexington.
U.S. Rt. 27, at Lexington.
U.S. Rt. 60, at Lexington.
U.S. Rt. 68, at Lexington.
U.S. Rt. 60, at Lexington.
BY-PASS U.S. Rt. 421, at Lexington.
Kentucky State Route 4, at Lexington.
Kentucky State Route 418, at Lexington.
Kentucky Secondary State Route 1975, near Spears.
Interstate 75, near Spears. (NO Interchange)
Kentucky Secondary State Route 1973, near Spears.
Interstate 75, near Spears.
Kentucky Secondary State Route 2328, near Spears.

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Branches of U.S. Rt. 421 in Fayette County.

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A BGS on WB KY St Rt 4.

A BGS on SB I-75.

A BGS on NB I-75.

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29 January 2023