U.S. Federal Route 41 runs north-south through Christian County. This runs along the Pennyrile Parkway. At Hopkinsville, it splits into tow highways, U.S. Rt. 41 and Alternate U.S. Rt. 41. U.S. Rt. 41 passes through the following towns in Christian County. Empire Crofton Hopkinsville Pembroke U.S. Rt. 41 is multi-plexed in Christian County. Kentucky State Route 107, at Hopkinsville. Kentucky State Route 109, at Hopkinsville. U.S. Rt. 68, at Hopkinsville. Kentucky State Route 80, at Hopkinsville. U.S. Rt. 41 intersects the following highways in Christian County. Kentucky State Route 407, near Mannington. Kentucky State Route 407, near Mannington. Kentucky Secondary State Route 1296, at Empire. Kentucky Secondary State Route 1348, at Crofton. Kentucky State Route 800, at Crofton. Kentucky Secondary State Route 1682, at Hopkinsville. Kentucky Secondary State Route 1007, at Hopkinsville. U.S. Rt. 68, at Hopkinsville. Kentucky State Route 80, at Hopkinsville. Kentucky State Route 107, at Hopkinsville. Kentucky State Route 109, at Hopkinsville. Kentucky State Route 107, at Hopkinsville. ALT U.S. Rt. 41, at Hopkinsville. U.S. Rt. 68, at Hopkinsville. Kentucky State Route 80, at Hopkinsville. Kentucky State Route 380, at Hopkinsville. Edward T Breathitt Pennyrile Parkway, at Hopkinsville. Kentucky State Route 109, at Hopkinsville. BY-PASS U.S. Rt. 68, at Hopkinsville. Kentucky State Route 115, at Pembroke. Kentucky Secondary State Route 1453, near Pembroke.
