Alternate U.S. Federal Route 41 runs due south from Hopkinsville to Tennessee. This is the main route connecting Hopkinsville and Interstate 24 to Fort Campbell, and each other. ALT. U.S. Rt. 41 passes through the following towns in Christian County. Hopkinsville Masonville Oak Grove ALT. U.S. Rt. 41 is multi-plexed in Christian County. Kentucky State Route 380, at Hopkinsville. ALT. U.S. Rt. 41 intersects the following highways in Christian County. U.S. Rt. 41, at Hopkinsville. U.S. Rt. 68, at Hopkinsville. Kentucky State Route 80, at Hopkinsville. Kentucky State Route 109, at Hopkinsville. Kentucky State Route 380, at Hopkinsville. Kentucky State Route 380, at Hopkinsville. Edward T. Breathitt Pennyrile Parkway, at Hopkinsville.
Kentucky Secondary State Route 1453, near Oak Grove.
Interstate 24, near Oak Grove. Kentucky State Route 117, near Oak Grove. Kentucky State Route 911, at Oak Grove. Kentucky State Route 400, near Edgoten.
BGS on SB Pennyrile. SB ALT. U.S. Rt. 41 on the southside of Hopkinsville. SB route marker. SB ALT. U.S. Rt. 41 near KY Sec 1027. SB ALT. U.S. Rt. 41 at I-24. BGS over SB ALT. U.S. Rt. 41 at I-24.
